Munavvar Zubaid Abdul SATTAR^*, Sheryar AFZAL

Department of Scientific Basis of Therapeutics, Faculty of Pharmacy, MAHSA University, Selangor, Malaysia (munavvar@mahsa.edu.my)

The adipose tissue as an object of study has dynamically entered the field of cardiology over the last decade. The communication between adipose tissue and other biological systems is accomplished through the expression of a large number of bioactive mediators, called adipokine or adipocytokines (Antoniades et al. 2009). The main adipocytokines are adiponectin (ADN), leptin, resistin, interleukin (IL-6), (Ryo et al. 2004), tumor necrosis factor-alpha (TNF-a) and the plasminogen activator-1 inhibitor (PAI-1). Adiponectin is distinguished by being not only the most abundant product of fat, but also for being one of the major involved in regulating various mechanisms in human body (Siasos, 2012). Adiponectin is a secreted protein consisting of 247 amino acids, produced exclusively by adipocytes. Adiponectin was independently identified by four laboratories; hence, the multiple names. Lodish laboratory first discovered adiponectin in 1995 as a protein named “Adipocyte Complement Related Protein of 30 kDa” (ACRP30) (Scherer et al. 1995).