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Category Archives: Journal Articles

A New Drug Design: Substances Excreted from The Body Serve as Deterrents Against Insect Bites


Citation: SATO, Erina; FOONG, Anthony FW A New Drug Design: Substances Excreted from The Body Serve as Deterrents Against Insect Bites JAS4QoL 2023, 9(1) 2 online at: https://as4qol.org/tlN6K
Categories: > Volume 9, > Wisdom Notes, Journal Articles, Volumes
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SATO; Erina * , FOONG; Anthony FW

A New Drug Design: Substances Excreted from The Body Serve as Deterrents Against Insect Bites

R&D for Product Development, Imex Japan Co. Ltd., 3F Imex Japan Building, 22 Shimomidori-cho, Shichihku, Kita-ku, Kyoto 603-8425, Japan 78imexfw@gmail.com

Many succumb to dengue, malaria, Zika, and yellow fever in tropical Asia and Africa. Dengue per se may cause hemorrhagic fever in 100-400 million people a year, although 80% of cases are mild or asymptomatic (according to World Health Organization). Of the carriers for these diseases, mosquitoes – Aedes aegypti (AA) species – is among the most rampant, common, and difficult to handle, because it is adapting, mutating, and evolving to become more resistant to the hitherto effective pyrethroid-based chemicals such as permethrin. As a result, many people have become infected with above-mentioned diseases, thereby severely lowering quality-of-life (QoL) of the affected. Recent surveys by a Japanese research team (KASAI Shinji et al.) in certain parts of Asia and Ghana have demonstrated growing region-dependent resistance to insecticides of some mosquito strains (recent 1000-fold vs previous 100-fold resistance): viz., insecticide levels that would normally kill 100% of mosquitoes in a sample will now kill ca. 7% of the insects. AA mosquitoes are the most troublesome species as these are the most common carriers for above-mentioned diseases.

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Hidden Curriculum in the Pharmacy Education: A Comparison of the Six-Year Curriculum With the Former Four-Year Curriculum


Citation: KOBAYASHI, Aya; KOBAYASHI, Yasuna Hidden Curriculum in the Pharmacy Education: A Comparison of the Six-Year Curriculum With the Former Four-Year Curriculum JAS4QoL 2023, 9(1) 1 online at: https://as4qol.org/Pprb9
Categories: > Full Papers, > Volume 9, Journal Articles, Volumes
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KOBAYASHI; Aya, KOBAYASHI; Yasuna

 

Department of Pharmacy Education, Showa University School of Pharmacy, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan (ayakoba408@pharm.showa-u.ac.jp)

This study investigated the “hidden curriculum” that exists side-by-side with the formal pharmacy education in the daily life of pharmacy students. Specifically, it focuses on whether pharmacy students acquire through extracurricular activities and during daily school life while attending the pharmacy schools constitute helpful learning that assists them in becoming pharmacists who make positive contributions to society and healthcare. We have also sought to determine which specific extracurricular activities and habits, etc., served to bolster their self-awareness as pharmacists. We conducted questionnaires and interviews and investigated the characteristic “hidden curriculum” these individuals experienced as students at pharmacy schools. Information gathered from a questionnaire revealed that the number of positive responses to the question: “In regard to extracurricular activities experienced in the time you were at a pharmacy school, did what you had learned help you as a pharmacist?” was 63.3% in the former four-year (4Yr) and 71.3% in the six-year (6Yr) cohorts. Based on information compiled from individual interviews, reasons why “extracurricular activities” were helpful as pharmacists were assigned to the categories of “identity,” “professionalism,” “peer effects,” “recognition of others.” It became clear that their extracurricular activities were of great importance to their work and attitudes as pharmacists, as they grew in self-responsibility and self-awareness as pharmacy professionals. The reason for this outcome is that the daily exposure to those experiences while in pharmacy school molded them into pharmacists without them being consciously aware of it. The study results make clear that extracurricular activities during student life were helpful as pharmacists. We conclude that the “hidden curriculum” played key role in the process of building self-awareness and a sense of responsibility required for pharmacists.

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Wonders from Nature in The Tropical Southeast Archipelago: Health from Jungles and Bushes


Citation: FOONG; Anthony FW Wonders from Nature in The Tropical Southeast Archipelago: Health from Jungles and Bushes JAS4QoL 2022, 8(1) 3 online at: https://as4qol.org/p6097
Categories: > Mini Reviews, > Volume 8, Journal Articles, Volumes
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FOONG; Anthony FW  

Imex Japan Co. Ltd. 3F, Imex Japan Bldg, 22 Shimomidori-cho, Shichiku, Kita-Ku, Kyoto 603-8425 JAPAN (78imexfw@gmail.com

There are thousands of plant species in the tropics: many, though, cannot survive in the temperatures and environments either too far north or south or on soils unfriendly to the typical tropical species. From these tropical plant species can be derived ingredients and extracts that provide holistic cures and heal many diseases that modern medicines often cannot treat.

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Churg-Strauss Syndrome or Eosinophilic Granulomatosis with Polyangiitis (EGPA): A Case Study of Using Steroid Combined with Functional Food for Treatment


Citation: NAKYAMA; Tomoharu, FOONG; Anthony FW Churg-Strauss Syndrome or Eosinophilic Granulomatosis with Polyangiitis (EGPA): A Case Study of Using Steroid Combined with Functional Food for Treatment JAS4QoL 2022, 8(1) 2 online at: https://as4qol.org/uDcpC
Categories: > Case Reports, > Volume 8, Journal Articles, Volumes
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NAKAYAMA; Tomoharu 1 , FOONG; Anthony FW 2 

Nakayama Clinic, 8-251-1, Kita-Itami, Itami City, Hyogo Prefecture 664-0831 JAPAN; (drnakayama888@nike.eonet.ne.jp

Imex Japan Co. Ltd. 3F, Imex Japan Bldg, 22 Shimomidori-cho, Shichiku, Kita-Ku, Kyoto 603-8425 JAPAN

A female patient, who complained of weight loss, suffered from pain with occasional numbness and tingling sensations in joints/muscles of her upper/lower extremities, and her abdominal regions, and suffered from general weakness with fatigue on a daily basis. Clinic visits revealed that she had Churg-Strauss syndrome1* or eosinophilic granulomatosis with polyangiitis (EGPA)*. Early clinical data showed high C-reactive protein (CRP: 5.1mg/dL) levels and eosinophil counts (9.2%), which improved to within normal ranges (CRP: <0.2 mg/dL; eosinophil counts: 3-5%) with 5-yr steroid treatment (prednisolone: 35 mg daily). However, EGPA-related signs and symptoms, AMY (amylase), and other blood and metabolic indexes registered unfavorable readings despite persistent steroid treatment. Her physical and biochemical conditions improved in a time-dependent fashion after combining steroid administration with complementary intake of functional food 3eMulti, which contained natural ingredients (such as docosahexaenoic acid, pecah beling leaf, pandan leaf, mangosteen peel extracts, nattokinase, lycopene, and beehive propolis) with multivariant purposes such as potent antioxidation, favorable blood vascular and cell-function properties. After 9-months of daily intake of the aforementioned functional food in addition to continuous steroid treatment, she recovered completely from the physical and biochemical deficits. To date, she has been enjoying good quality of life (QoL), with above-mentioned combination treatment continuing without any adverse effects. When medications alone are insufficient to treat an idiopathological disease, a combination of medication and functional food intake (particularly with effect-complementary ingredients) may improve the patient’s condition so they may be able to accommodate or normalize the pathological condition. This may lead to a more wholesome, in terms of QoL, living conditions for patients suffering from intractable disease. 

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It is Not Easy to Find a Clean and Functional Public Toilet in Many Countries: Lessons to Learn from Japan


Citation: SATO, N.; ISHII, E. It is Not Easy to Find a Clean and Functional Public Toilet in Many Countries: Lessons to Learn from Japan JAS4QoL 2022, 8(1) 1 online at: https://as4qol.org/xAJT1
Categories: > Volume 8, > Wisdom Notes, Journal Articles, Volumes
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SATO; NorikoISHII; Erina  

Imex Japan Co. Ltd., 3F Imex Japan Building, 22 Shimomidori-cho, Shichiku, KitaKu, Kyoto 603-8425, JAPAN

Traveling in Europe, the United States, and most countries in Asia, it is always a painful and embarrassing moment when nature calls. For people living in Japan especially, the situation maybe unbearable when a language barrier arises as well. All these come back to the one and one only question:  Why are public toilets or washrooms not readily available outside Japan? The answer to this question goes back to the 19th century when a well-meaning reformer, Augustus Gardner spoke out in 1862: “Any man, and far more, any woman may walk from one end of this city to the other, in the most dire torture, without finding the relief to the necessities of the body, without such indecent exposure of the person as would render the individual liable to arrest and fine by the civic authorities.” 

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Be a Good and Reliable Co-Driver


Citation: SATO, N. Be a Good and Reliable Co-Driver JAS4QoL 2021, 7(1) 2 online at: https://as4qol.org/jwsWt
Categories: > Volume 7, > Wisdom Notes, Journal Articles, Volumes
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SATO; Noriko  

Chief Executive Officer, Imex Japan Co Ltd, 22-8 Shimomidori-cho, Shinchiku, Kita-ku, Kyoto 603-8425, Japan

For drivers to enjoy driving a vehicle, whether they are maneuvering forward or negotiating a curve, he/she should be free to steer, slow down, accelerate, and brake without the distraction of uneccessary noises or disturbances around them. At the same time, a person driving a car is often accompanied by companions, friends, or family members. In such situations, there is usually a so-called “co-driver” in the seat next to them.

All in all, co-drivers will greatly help facilitate the driver’s task by adhering to the following guidelines.

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A Case Study on Functional Food Intake in a Diabetic Patient: No Such Thing as a Magic Bullet Part-II


Citation: FW FOONG, A.; SATO, K. A Case Study on Functional Food Intake in a Diabetic Patient: No Such Thing as a Magic Bullet Part-II JAS4QoL 2021, 7(1) 2 online at: https://as4qol.org/QLRiK
Categories: > Full Papers, > Volume 7, Journal Articles, Volumes
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A Case Study on Functional Food Intake in a Diabetic Patient: No Such Thing as a Magic Bullet Part-II

FOONG; Anthony FW SATO; Erina2  

R&D Department, Imex Japan Co Ltd, 22-8 Shimomidori-cho, Shinchiku, Kita-ku, Kyoto 603-8425, Japan (78imexfw@gmail.com

BACKGROUND: Useful ingredients in functional foods A and B previously improved certain physical symptoms (PSs) deficits due to ageing; however, blood sugar levels (monitored as glycemated hemoglobin or HbA1C) of a type-2 diabetic were unsatisfactory. We investigated the probable factors by focusing on the supply source, types and concentrates of sugar-regulating substances in ingredient mulberry leaf extract (MLE) as the extract was previously not well-defined. The revised functional food C (replaced previously known B), where all ingredients remained the same in quantity and supply sources, except MLE where the useful ingredient 1.2% 1-deoxynojirimycin (DNJ) was defined and obtained from a new supplier Z. METHODS: Volunteer patient P, who led a sedentary lifestyle, had continued intake of functional food A and complemented A with C after 2 control readings had been taken. Controls and blood analytical data were respectively monitored before and after combined A+C intake at 3-month (3-mo) intervals. Blood pressure (BP), body mass index (BMI), and other metabolic indexes were taken before (A alone) and after combined A+C intake. P led his usual normal life without dietary restrictions. PSs were also monitored before and after combined A+C intake. RESULTS: Blood pressure (BP) was normal, with slight improvement in BMI values. Total cholesterol (T-Cho), triglycerides (TG) levels varied in a similar pattern, which eventually registered normal after 9-mo combined A+C intake. HbA1c levels scored impressive improvements in a time-dependent manner: i.e. decreasing from 8.0 and 9 (controls) to 7.5, 6.9, and 6.8 at 3-, 6- and 9-mo combined A+C intakes, respectively. Improved PSs were well maintained. DISCUSSION: The BMI improved from overweight to normal status. Rebounds in T-Cho (3-, 6-mo) and TG (6-mo) levels were probably associated with high-calorie sweets taken in August. The most impressive finding in this study is the marked improvement in HbA1c findings. Replacement of MLE from a new source Z with defined 1-deoxynojirimycin (DNJ) concentrate made all the difference: the alpha-glucosidases-inhibiting DNJ, fagomine, and other active sugar-regulating components in MLE may have lowered blood sugar levels, thus improving HbA1c values. Functional foods comprising effective ingredients would most likely elicit useful effects, if the active ingredient with a defined concentrate was used.

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Development and Evaluation of a Community Consumer Education Program for Parents and Children


Citation: SUZUKI, M. Development and Evaluation of a Community Consumer Education Program for Parents and Children JAS4QoL 2021, 7(1) 1 online at: https://as4qol.org/6PMMS
Categories: > Mini Reviews, > Volume 7, Journal Articles, Volumes
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Development and Evaluation of a Community Consumer Education Program for Parents and Children

SUZUKI; Mihoko 

R&D Department, Imex Japan Co Ltd, 22-8 Shimomidori-cho, Shinchiku, Kita-ku, Kyoto 603-8425, Japan  (mihoyuki2014@gmail.com

Although the Consumer Education Promotion Act in Japan stipulates that "Education deepens the understanding of participation in planning for consumers forming a society," the goals for consumers – especially for elementary school children and their parents – have not been well established. A "community consumer education program" was developed, implemented, and evaluated according to the "image-map" framework for the consumer education system. Participant surveys using questionnaire in this study revealed that the program helped children to develop clear awareness of the issue of food waste at home and in society, developing a greater concern for the socially vulnerable. Adults were motivated to learn more about ethical consumption and developed improved awareness of the social consequences of consumption. Parent-child communication via this program enabled adults and children to learn from each other.

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A Case Study on Functional Food Intake in a Diabetic Patient: No Such Thing as a Magic Bullet Part-I


Citation: FW FOONG, A.; HATTA, K. A Case Study on Functional Food Intake in a Diabetic Patient: No Such Thing as a Magic Bullet Part-I JAS4QoL 2020, 6(1) 3 online at: https://as4qol.org/TXZbX
Categories: > Full Papers, > Volume 6, Journal Articles, Volumes
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A Case Study on Functional Food Intake in a Diabetic Patient: No Such Thing as a Magic Bullet Part-I

FOONG; Anthony FW HATTA; Kanji

R&D Department, Imex Japan Co Ltd, 22-8 Shimomidori-cho, Shinchiku, Kita-ku, Kyoto 603-8425, Japan  (78imexfw@gmail.com

Department of Psychiatric Nursing, School of Nursing, Takarazuka University, 16-13-1, Shibata, Kita-ku, Osaka 530-0012, Japan

The present study reaffirmed that single-use of disorder-orientated functional foods may not be effective in resolving certain muscle- and orientation-relevant health problems. A male diabetic patient P on a functional food A (a product for blood pressure control) intake for more than 10 yr suffered from certain physical symptoms (PSs) such as forearm Grip-holding (FGH) muscular strength (PS-1), hindlimb joints (HJs) discomfort (PS-2), physical balance or orientation on one-legged standing (PS-3), and urination flow onset-latency and duration of complete emptying (PS-4) as well as poor metabolic indexes such as high levels of total cholesterols (T-Cho), low-density lipoprotein-cholesterols (LDL-C), triglycerides (TG), and HbA1C. When intake of A was complemented with daily product B, intake all PSs improved in a time-dependent manner; with different PS improvements requiring different intake duration: shorter intake duration for PS-1 (3-wk intake and thereafter), and longer intake durations for other PSs (at least more than 3-month intake). Additionally, high levels of T-Cho and relevant indexes were also improved over time with different intake durations, although the blood sugar levels (HbA1c) were unaffected. T-Cho (3-month intake), LDL-C (3-month intake), TG (after 6-month intake) were restored after different intake durations; however, blood sugar levels (HbA1c) were unaffected despite mulberry leaf extract having been documented to reduce blood sugar levels. Improvements of PSs and metabolic indexes were probably due to complementary effects of B whose effects in combination with A improved metabolic activity, nutritional, blood circulation and neurological effects and may have contributed to the favorable outcomes in this study. 

Keywords: 

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Development of a Free-Electron Laser in the Terahertz Region


Citation: ISOYAMA; G. Development of a Free-Electron Laser in the Terahertz Region JAS4QoL 2020, 6(1) 2 online at: https://as4qol.org/2JCCK
Categories: > Mini Reviews, > Volume 6, Journal Articles, Volumes
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Development of a Free-Electron Laser in the Terahertz Region

Isoyama; Goro

Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan (isoyama@sanken.osaka-u.ac.jp

We have been developing a free-electron laser (FEL) in the far-infrared or terahertz (THz) region for higher intensity and stability, using the L-band (1.3 GHz) electron linear accelerator (linac) at the Institute of Scientific and Industrial Research (ISIR), Osaka University. The FEL was progressively upgraded, and the maximum energy of micropulses, which form an FEL macropluse of a duration of some microseconds, reached 260 μJ at a wavelength around 65 μm or a frequency around 4.6 THz, which is an order of magnitude higher than micropulse energies obtained in other FELs in this wavelength or frequency range. Experiments have begun using high-intensity narrow-band terahertz radiation from the FEL. This paper summarized the progress of the FEL and its application experiments.

Keywords: Free Electron Laser (FEL), Electron, Linear Accelerator (Linac), Terahertz (THz), Far-Infrared

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