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A New Drug Design: Substances Excreted from The Body Serve as Deterrents Against Insect Bites

SATO, Erina; FOONG, Anthony FW A New Drug Design: Substances Excreted from The Body Serve as Deterrents Against Insect Bites JAS4QoL 2023, 9(1) 2 online at: https://as4qol.org/tlN6K

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SATO; Erina * , FOONG; Anthony FW

R&D for Product Development, Imex Japan Co. Ltd., 3F Imex Japan Building, 22 Shimomidori-cho, Shichihku, Kita-ku, Kyoto 603-8425, Japan 78imexfw@gmail.com

Many succumb to dengue, malaria, Zika, and yellow fever in tropical Asia and Africa. Dengue per se may cause hemorrhagic fever in 100-400 million people a year, although 80% of cases are mild or asymptomatic (according to World Health Organization). Of the carriers for these diseases, mosquitoes – Aedes aegypti (AA) species – is among the most rampant, common, and difficult to handle, because it is adapting, mutating, and evolving to become more resistant to the hitherto effective pyrethroid-based chemicals such as permethrin. As a result, many people have become infected with above-mentioned diseases, thereby severely lowering quality-of-life (QoL) of the affected. Recent surveys by a Japanese research team (KASAI Shinji et al.) in certain parts of Asia and Ghana have demonstrated growing region-dependent resistance to insecticides of some mosquito strains (recent 1000-fold vs previous 100-fold resistance): viz., insecticide levels that would normally kill 100% of mosquitoes in a sample will now kill ca. 7% of the insects. AA mosquitoes are the most troublesome species as these are the most common carriers for above-mentioned diseases.

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